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KMID : 0380620210530060715
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Korean Journal of Food Science and Technology
2021 Volume.53 No. 6 p.715 ~ p.721
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Effect of 1,2,3,4,6-penta-O-gallolyl-β-?-glucose on markers of cognitive function in human neuroblastoma SK-N-SH cell line
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Yoon Hyeon-Seok
Park So-Yeon
Kim Yoon-Hee
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Abstract
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Cognitive impairment and Alzheimer's disease are serious social problems associated with the rising elderly population in Korea. 1,2,3,4,6-Penta-O-galloyl-β-?-glucopyranose (PGG) is a gallotannin isolated from medicinal plants such as Rhus chinensis. This study was performed to evaluate the effect of PGG on biomarkers related to cognitive function in human neuroblastoma SK-N-SH cells. Inhibition of acetylcholinesterase (AChE) activity is considered to be one of the main therapeutic strategies. PGG inhibited AChE activity in the test tube as well as in SK-N-SH cells. In addition, PGG induced protein and mRNA expression of brain-derived neurotrophic factor (BDNF), which is a mammalian neurotrophin that plays major roles in the development, maintenance, repair, and survival of neuronal populations. As one of the underlying molecular mechanisms that induce BDNF expression, PGG induced the activation of Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII)-cAMP response element binding protein (CREB) pathway. In conclusion, PGG may be an useful material for improving cognitive function.
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KEYWORD
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penta galloyl glucose, tannin, acetylcholineesterase, brain-derived neurotophic factor, cognitive function
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